Photoredox cross-coupling: Ir/NidDual catalysis for the synthesis of Benzylic Ethers
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Date
2015Metadata
Citation
Karakaya, I., Primer, D. N., Molander, G. A., (2015). Photoredox cross-coupling: Ir/NidDual catalysis for the synthesis of Benzylic Ethers. Organic Letters, 17(13), 3294-3297. DOI: 10.1021/acs.orglett.5b01463Abstract
Single-electron transmetalation has emerged as an enabling paradigm for the cross-coupling of C-sp(3) hybridized organotrifluoroborates. Cross-coupling of alpha-alkoxymethyl-trifluoroborates with aryl and heteroaryl bromides has been demonstrated by employing dual catalysis with a combination of an iridium photoredox catalyst and a Ni cross-coupling catalyst. The resulting method enables the alkoxymethylation of diverse (hetero)arenes under mild, room-temperature conditions.