Copper-mediated N-arylation of methyl 2-aminothiophene-3-carboxylate with organoboron reagents
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Tarih
2015Üst veri
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Rizwan, K., Karakaya, I., Heitz, D., Zubair, M., Rasool, N., Molander, G. A., (2015). Copper-mediated N-arylation of methyl 2-aminothiophene-3-carboxylate with organoboron reagents. Tetrahedron Letters, 56(49), 6839-6842. DOI: 10.1016/j.tetlet.2015.10.080Özet
A practical protocol for the synthesis of N-arylated methyl 2-aminothiophene-3-carboxylate has been developed via Chan Lam cross-coupling. The desired products were synthesized by cross-coupling of methyl 2-aminothiophene-3-carboxylate with both arylboronic acids and potassium aryltrifluoroborate salts in moderate to good yields. A broad range of functional groups was well tolerated. (C) 2015 Elsevier Ltd. All rights reserved.