Enantioselective Allylic Alkylation Catalyzed by Novel C2-Symmetric Bisphosphinites

Abstract

In this article, we present our results concerning new C-2-symmetric bisphosphinites with a (1R, 2R)-1,2-bis([1,1':3',1 ''-terphenyl]-5'-yl) ethane backbone. For the given chirality of the backbone, derivatives with aromatic and aliphatic substituents at the donor P-atoms were synthesized with moderate yields in a straightforward manner. These compounds were evaluated in the Pd-0-catalyzed enantioselective allylic alkylations (up to 67% ee).