Synthesis of aminomethyl quinazoline based ruthenium (II) complex and its application in asymmetric transfer hydrogenation under mild conditions

Abstract

The new chiral aminomethyl quinazoline (amq) type ligand derived from L-phenylalanine was synthesized and coordinated with [RuCl2(PPh3) dppb] to obtain ruthenium(II) complex. This catalyst displayed considerable reactivity (up to 97% ee and 99% conversion) in the asymmetric transfer hydrogenation of ketones using 2-propanol as a hydrogen source in the presence of NaOiPr. (C) 2016 Elsevier B.V. All rights reserved.