Synthesis and biological evaluation of (S)-4-aminoquinazoline alcohols

Basit Öğe Kaydı
dc.authoridKarabuga, semistan/0000-0001-9753-206X
dc.authoridGulluce, Medine/0000-0002-5957-8259
dc.authoridCakici, Murat/0000-0002-7020-0302;
dc.contributor.authorCakici, Murat
dc.contributor.authorCatir, Mustafa
dc.contributor.authorKarabuga, Semistan
dc.contributor.authorKilic, Hamdullah
dc.contributor.authorUlukanli, Sabri
dc.contributor.authorGulluce, Medine
dc.contributor.authorOrhan, Furkan
dc.date.accessioned2025-08-12T08:25:07Z
dc.date.issued2010
dc.departmentOsmaniye Korkut Ata Üniversitesi
dc.description.abstractA simple synthetic method for the preparation of enantiomerically pure (S)-4-aminoquinazoline alcohols from (S)-quinazolinone alcohols by key steps including chlorination, nucleophilic ipso substitution, and deacetylation is presented. Mutagenic and antimutagenic properties of the (S)-4-aminoquinazoline alcohols were investigated by using Salmonella typhimurium TA1535, and Escherichia colt WP2uvrA tester strains at 0.01, 0.1, and 1 mu g/plate concentrations. (S)-4-aminoquinazoline alcohols were found to be genotoxically safe at the tested concentrations. Among the tested (S)-4-aminoquinazoline alcohols, the best antimutagenic activity was obtained with a methyl derivative at 0.1 mu g/plate dose. (C) 2010 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [TBAG-108T116]
dc.description.sponsorshipThe financial support from the Scientific and Technological Research Council of Turkey (TUBITAK) (TBAG-108T116) is gratefully acknowledged. In addition, the authors would like to thank Dr. Graham Eaton from the Leicester University for the HRMS measurements.
dc.identifier.doi10.1016/j.tetasy.2010.05.040
dc.identifier.endpage2031
dc.identifier.issn0957-4166
dc.identifier.issue16
dc.identifier.scopusqualityN/A
dc.identifier.startpage2027
dc.identifier.urihttps://doi.org/10.1016/j.tetasy.2010.05.040
dc.identifier.urihttps://hdl.handle.net/20.500.12502/4743
dc.identifier.volume21
dc.identifier.wosWOS:000281977500013
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofTetrahedron-Asymmetry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250812
dc.subjectMicrowave-Assisted Synthesis
dc.subjectVitro Antitumor-Activity
dc.subject4-Aminoquinazoline Derivatives
dc.subjectInhibitors
dc.subjectAlkaloids
dc.titleSynthesis and biological evaluation of (S)-4-aminoquinazoline alcohols
dc.typeArticle

Dosyalar

Koleksiyon

Web of Science İndeksli Yayınlar Koleksiyonu